朱小蘭,1986.12,女,醫學博士,世界杯正规买球app婦産科學碩士生導師,江蘇省“333 工程”第三層次培養對象,“六大人才高峰”培養對象,鎮江市“169 工程”科技骨幹,鎮江市有突出貢獻的中青年專家,鎮江市十大傑出青年。
教育與研究經曆
2018.10-2019.09 麻省總醫院(哈佛醫學院)訪問學者
2013.09-2016.06 世界杯正规买球app 醫學博士
2009.09-2012.06 世界杯正规买球app 醫學碩士
2004.09-2009.06 世界杯正规买球app 醫學學士
工作經曆
2014.09-至今 鎮江市婦幼保健院 生殖醫學中心 主治醫師,副主任醫師
2012.07-2014.08 鎮江市婦幼保健院 婦産科 住院醫師
研究方向
卵巢早衰的基礎與臨床研究
婦瘤耐藥的基礎與臨床研究
近年來主持的省部級以上科研項目
國家自然科學基金 (81402165);
江蘇省社會發展項目(BE2018693);
江蘇省自然科學基金 (BK20171311);
江蘇省自然科學基金(BK20131241);
江蘇省六大高峰人才項目(2016-WSW-125)
江蘇省333科研項目
近年來獲得的科技獎項
江蘇省科技進步三等獎(1/7)
江蘇省新技術引進一等獎(1/3)
江蘇省婦幼新技術引進二等獎(1/3)
鎮江市科技進步一等獎(1/5)
近年來發表的主要論文
Zhu XL, Shen HL,Yin XM, Long LL, Xie CJ, Liu YQ, Hui LL, Lin X, Fang Y, Cao Y, Xu Y, Li M, Xu WL and Li YF. miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin. Oncogene, 2016,3(5):323-332.
Zhu XL, Shen HL, Xu WL.et al. Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype, Journal of Experimental & Clinical Cancer Research,2019,38:81.
Hao Chen, Haibo Yang, Xiaolan Zhu(Co-first author). m5C Modification of mRNA Serves a DNA Damage Code to Promote Homologous Recombination. Nature communication,2020.
Yang ML, Lin L, Zhu XL (Corresponding Author), .et al. Bone marrow mesenchymal stem cells derived exosomal miR-144-5p improved rat ovary function after chemotherapy-induced ovary failure by targeting PTEN. LABORATORY INVESTIGATION,2019, doi.org/10.1038/s41374-019-0321-y.
Zhu XL, Li YF.miR-124 regulation of NFATC1 and atherosclerosis in APOE-deficient mice, JACC, 2015,66(16):63-64.
Zhu XL, Li YF, Xie CJ, et al. miR-145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6.Int J Cancer,2014.135(6):1286-96.
Zhu XL, Shen HL,Yin XM, et al, IL-6R/STAT3/miR-204 feedback loop contributes to cisplatin resistance of epithelial ovarian cancer cells. Oncotarget, 2017,8(24): 39154-39166.
Zhu XL, Li YF, Shen HL, et al. miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6. FEBS lett. 2013.587(1):73-81.
Zhu XL, Li YF, Shen HL, et al. miR-137 restoration sensitizes multidrug-resistant MCF-7/ADM cells to anticancer agents by targeting YB-1. Acta biochimica et biophysica Sinica 2013,45(2):80-86.
Zhu XL, Li H, Long LL, et al. miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factorA. Acta biochimica et biophysica Sinica, 2012.44(6):519-526.