Curriculum Vitae

Songlei Xue

Phone: +86-152****8860

Email: xuesl2013@hotmail.com

International Genomics Research Center, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013

Education

Sep. 2009- Jun.2013

Bachelor , College of Animal Science and Technology, Yangzhou University

Apr. 2013- May.2013

Visiting scholar, Institute of Basic Research, Chinese Academy of Medical Sciences

Sep. 2013 - Jun. 2016

Master, Institute of Epigenetics & Epigenomics (IEE), Yangzhou University

Sep. 2016 – Dec.2020

PhD., Institute of Epigenetics & Epigenomics (IEE), Yangzhou University

Aug.2018

Visiting scholar, University of Western Australia (UWA), Australia

Nov. 2019 – Nov.2020

Joint doctoral training,Washington State University (WSU), United States

Apr. 2021 - Present

Postdoctoral fellow, International Genomics Research Center (IGC), Jiangsu University

Ph.D thesis:

Study of epigenetic mechanism of mesenchymal stem cells (MSC) and exosomes.

Master thesis:

Comparative analysis of transposition, gene and enhancer trapping efficiency of SB, PB, and Tol2 transposons in zebrafish.

Research projects

1)     2012-2013：

Gene transfer in chicken embryos mediated with Sleeping Beauty Transposon.

Jiangsu project of scientific research innovation for University Students (2012JSSPITP1406), Funded by Yangzhou University and Education Department of Jiangsu Province

2)     2014-2015:

Investigation of the biological role of active Tc1 transposon in the early development of zebrafish embryos.

Jiangsu postgraduate research innovation project (KYLX-1357), Funded by Yangzhou University and Education Department of Jiangsu Province

3)     2018-2019:

Study on the regulation mechanism of RNA methylation modification on developmental process Jiangsu postgraduate research innovation project (XKYLX18-095), Funded by Yangzhou University

Publications

Xue S, Xu H, Sun Z, et al. Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration[J]. Biochemical and Biophysical Research Communications, 2019.（IF=2.985）

Sun Z, Xue S, Zhang M, et al. Aberrant NSUN2-mediated m 5 C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma[J]. Oncogene, 2020: 1-14. （IF=7.971）

Shen D, Xue S, Chan S, et al. Enhancer Trapping and Annotation in Zebrafish Mediated with Sleeping Beauty, piggyBac and Tol2 Transposons[J]. Genes, 2018, 9(12): 630.（Co-first-auther，IF=3.191）

Sun Z, Xue S, Xu H, et al. Effect of NSUN2 deficiency on the mRNA 5-methylcytosine modification and gene expression profile in HEK293 cells, Epigenetics, 2018 Dec 11. [Epub ahead of print] PMID:30526041.（IF=4.918）

Sun, Z, Xue, S, Xu, H, et al. Expression profiles of long noncoding RNAs associated with the NSUN2 gene in HepG2 cells. Molecular Medicine Reports. (IF=1.922)

Yang Z, Chen S, Xue S, et al. Injection of an SV40 translational terminator causes embryonic lethality: A possible zebrafish model to screen for non-homologous end-joining inhibitors，OncoTargets and Therapy. 2018 Aug 17;11:4945-4953. PMID: 30154663. (IF=3.046)

Yang Z, Chen S, Xue S, et al. Generation of Cas9 transgenic zebrafish and its application in establishing ERV-deficient animal model, Biotechnology Letters. 2018 Sep 22. PMID:30244429 (IF=1.846)

Bo Gao; Dan Shen; Songlei Xue, et al. The contribution of transposable elements to size variations between four teleost genomes. Mobile DNA, 2016,7(4). (IF=4.23)

Hu X, Chen S, Jia C, Xue S, Dou C, Dai Z, Xu H, Sun Z, Geng T and Cui H*. Gene expression profiling and analyses of long non-coding RNAs using RNA-Seq in chicken embryonic fibroblast cells infected by ALVJ virus. Archives of Virology, 2018 Mar;163(3):639-647. PMID: 29198037. (IF=2.058 )

Bo Gao, Saisai Wang, Yali Wang, Dan Shen, Songlei Xue, Cai Chen, Hengmi Cui, Chengyi Song. Low diversity, activity, and density of transposable elements in five avian genomes. Funct Integr Genomics, 2017, 17(4):427–439. (IF=3.496).

Saisai Wang, Yali Wang, Dan Shen, Li Zhang, Songlei Xue, Hengmi Cui, Chengyi Song, Bo Gao. Efficient Gene Transfer into Chicken Gonads by Combining Transposons with Polyethylenimine. Journal of Agricultural Science, 2016, 8 (10).

XUE Song-Lei, SHI Yun-Qiang, CHEN Cai, SHEN Dan, LI Qing-Ping, SONG Cheng-Yi, CUI Heng-Mi. GAO Bo.2016. Transgenic Efficiency of the Cytoplasmic Microinjection Technique Mediated with Different Transposons. Journal of Agricultural Biotechnology, 24(1): 151~156.

XUE Song-Lei, ZHANG Li, XIE Yu-Xiu, LI Qing-Ping, FENG Xiao-Jun, SHEN Dan, SONG Cheng-Yi ,GAO Bo.2013. The Enhanced Green Fluorescent Protein Gene(EGFP) Transfer Mediated by Sleeping Beauty Transposon in Chicken(Gallus domesticus) Embryo. Journal of Agricultural Biotechnology, 21(2): 185~191.

Patents

[1] A method for constructing a zebrafish heart-specific model and related vectors, Yangzhou University. CN201810941364.8.[P].2018-08-17.

[2] A method for rapid screening of model animals of zebrafish, Yangzhou University. CN201711157630.X [P].2017-11-20.

[3] An improved method for hatching and collecting brine shrimp, Yangzhou University. CN201810659207.X [P].2018-06-25.

[4] A method for rapid expansion of paramecium, Yangzhou University. CN201711441939.1 [P].2017-12-27.

[5] An HEK293 cell line knocked out by the RNA methylase TDMMT1 gene and its construction method, Yangzhou University. CN201810043530.2 [P].2018-1-17.

[6] A ZB transposon system and its mediated gene transfer method, Yangzhou University. CN201510429987.3 [P].2015-11-04.

[7] A gene transfer system and method specific to avian primordial germ cells, Yangzhou University. CN201610035065.9 [P].2016-04-27.